An instrumental puzzle: the modular integration of AOLI

The Adaptive Optics Lucky Imager, AOLI, is an instrument developed to deliver the highest spatial resolution ever obtained in the visible, 20 mas, from ground-based telescopes. In AOLI a new philosophy of instrumental prototyping has been applied, based on the modularization of the subsystems. This modular concept offers maximum flexibility regarding the instrument, telescope or the addition of future developments.Comment: 10 pages, 8 figures, Proc. SPIE 9908, Ground-based and Airborne Instrumentation for Astronomy VI, 99082Z (August 9, 2016

A counterfactual impact evaluation of a bilingual program on students’ grade point average at a spanish university

This observational study intends to estimate the causal effects of an English as a Medium of Instruction (EMI) program (as predictor) on students Grade Point Average (GPA) (as outcome) at a particular University in Spain by using a Counterfactual Impact Evaluation (CIE). The need to address the crucial question of causal inferences in EMI programs to produce credible evidences of successful interventions contrasts, however, with the absence of experimental or quasi-experimental research and evaluation designs in the field. CIE approach is emerging as a methodologically viable solution to bridge that gap. The program evaluated here consisted in delivering an EMI program in a Primary Education Teacher Training Degree group. After achieving balance on the observed covariates and recreating a situation that would have been expected in a randomized experiment, three matching approaches such as genetic matching, nearest neighbor matching and Coarsened Exact Matching were used to analyze observational data from a total of 1288 undergraduate students, including both treatment and control group. Results show unfavorable effects of the bilingual group treatment condition. Potential interpretations and recommendations are provided in order to strengthen future causal evidences of bilingual education programs’ effectiveness in Higher Education.This work was supported by the Junta de Andalucía-funded Proyecto de Excelencia: “Análisis y Garantía de Calidad de la Educación Superior Plurilingüe en la Educación Superior de Andalucía [Junta de Andalusia-funded Project of Excelence: Analysis and Warrantee of the Quality of Plurilingual Higher Education in Andalucia] (AGCEPESA; Grant Agreement No. P12-SEJ − 1588)

Differences in n-type doping efficiency between Al- and Ga-ZnO films

A careful and wide comparison between Al and Ga as substitutional dopants in the ZnO wurtzite structure is presented. Both cations behave as n-type dopants and their inclusion improves the optical and electrical properties of the ZnO matrix, making it more transparent in the visible range and rising up its electrical conductivity. However, the same dopant/Zn ratio leads to a very different doping efficiency when comparing Al and Ga, being the Ga cation a more effective dopant of the ZnO film. The measured differences between Al- and Ga-doped films are explained with the hypothesis that different quantities of these dopant cations are able to enter substitutionally in the ZnO matrix. Ga cations seem to behave as perfect substitutional dopants, while Al cation might occupy either substitutional or interstitial sites. Moreover, the subsequent charge balance after doping appear to be related with the formation of different intrinsic defects that depends on the dopant cation. The knowledge of the doped-ZnO films microstructure is a crucial step to optimize the deposition of transparent conducting electrodes for solar cells, displays, and other photoelectronic devices.Ministerio de Ciencia e Innovación TEC2007-60996, MAT2008-06858-C02-02, MAT2008- 06330, TEC2010-16700FUNCOAT CSD2008-00023- CONSOLIDER INGENIOSonderforschungsbereich SFB 76

Development and validation of a nomogram to predict kidney survival at baseline in patients with C3 glomerulopathy

Background C3 glomerulopathy is a rare and heterogeneous complement-driven disease. It is often challenging to accurately predict in clinical practice the individual kidney prognosis at baseline. We herein sought to develop and validate a prognostic nomogram to predict long-term kidney survival. Methods We conducted a retrospective, multicenter observational cohort study in 35 nephrology departments belonging to the Spanish Group for the Study of Glomerular Diseases. The dataset was randomly divided into a training group (n = 87) and a validation group (n = 28). The least absolute shrinkage and selection operator (LASSO) regression was used to screen the main predictors of kidney outcome and to build the nomogram. The accuracy of the nomogram was assessed by discrimination and risk calibration in the training and validation sets. Results The study group comprised 115 patients, of whom 46 (40%) reached kidney failure in a median follow-up of 49 months (range 24?112). No significant differences were observed in baseline estimated glomerular filtration rate (eGFR), proteinuria or total chronicity score of kidney biopsies, between patients in the training versus those in the validation set. The selected variables by LASSO were eGFR, proteinuria and total chronicity score. Based on a Cox model, a nomogram was developed for the prediction of kidney survival at 1, 2, 5 and 10 years from diagnosis. The C-index of the nomogram was 0.860 (95% confidence interval 0.834?0.887) and calibration plots showed optimal agreement between predicted and observed outcomes. Conclusions We constructed and validated a practical nomogram with good discrimination and calibration to predict the risk of kidney failure in C3 glomerulopathy patients at 1, 2, 5 and 10 years.ACKNOWLEDGEMENTS: Work on this study was supported by the Instituto de Salud Carlos III / Fondo Europeo de Desarrollo Regional (ISCIII/FEDER; grants PI16/01685 and PI19/1624) and Red de Investigación Renal (RD12/0021/0029; to M.P.) and the Autonomous Region of Madrid (S2017/BMD-3673; to M.P.). S.R.d.C. is supported by the Ministerio de Economia y Competitividad (grant PID2019-104912RB-I00) and the Autonomous Region of Madrid (grant S2017/BMD-3673). None of the funders had any role in the study design, data collection, analyses, reporting or decision to submit for publication

Uncovering the deeply embedded active galactic nucleus activity in the nuclear regions of the interacting galaxy Arp 299

Alonso-Herrero, A. et al.We present mid-infrared (MIR) 8-13 μm spectroscopy of the nuclear regions of the interacting galaxy Arp 299 (IC 694+NGC 3690) obtained with CanariCam (CC) on the 10.4 m Gran Telescopio Canarias (GTC). The high angular resolution (∼0.″3-0.″6) of the data allows us to probe nuclear physical scales between 60 and 120 pc, which is a factor of 10 improvement over previous MIR spectroscopic observations of this system. The GTC/CC spectroscopy displays evidence of deeply embedded active galactic nucleus (AGN) activity in both nuclei. The GTC/CC nuclear spectrum of NGC 3690/Arp 299-B1 can be explained as emission from AGN-heated dust in a clumpy torus with both a high covering factor and high extinction along the line of sight. The estimated bolometric luminosity of the AGN in NGC 3690 is 3.2 ± 0.6 × 1044 erg s-1. The nuclear GTC/CC spectrum of IC 694/Arp 299-A shows 11.3 μm polycyclic aromatic hydrocarbon emission stemming from a deeply embedded (AV ∼ 24 mag) region of less than 120 pc in size. There is also a continuum-emitting dust component. If associated with the putative AGN in IC 694, we estimate that it would be approximately five times less luminous than the AGN in NGC 3690. The presence of dual AGN activity makes Arp 299 a good example to study such phenomena in the early coalescence phase of interacting galaxies. © 2013. The American Astronomical Society. All rights reserved.The following Spanish Plan Nacional de Astronomía y Astrofísica grants are acknowledged: AYA2009-05705-E (A.A.H., P.E., C.R.A., and M.P.S.), AYA2010-21887-C04 (C.R.A. and J.M.R.E.), AYA2010-18029 (A.A.R.), AYA2010-21161-C02-01 (L.C.), and AYA2012-39168-C03-01 (J.M.R.E. and O.G.M.). A.A.R. also acknowledges financial support through the Ramón y Cajal fellowships and Consolider-Ingenio 2010 CSD2009-00038. C.P. and C.M.T. acknowledge support from NSF grants 0904421 and AST-903672, respectively.Peer Reviewe

HAEMATOLOGICAL AND BIOCHEMESTRY SERUM VALUES OF COMMON WOLLY MONKEY (Lagothrix lagotricha) REAREDIN SEMI-CAPTIVITY IN THE PERUVIAN TROPICS

El objetivo de este estudio fue determinar los valores hematológicos y de bioquímica sérica de una población de monos choros (Lagothrix lagotricha) que se encontraban en semicautiverio en el Centro de Rescate y Rehabilitación Ikama peru, en Lagunas, Loreto. Se trabajó con 40 monos, 12 machos y 28 hembras entre juveniles, sub-adultos y adultos en aparente buen estado de salud. Los valores hematológicos fueron similares, los niveles de triglicéridos y de AST estuvieron elevados y los de proteínas totales yALP estuvieron bajos en relación a estudios realizados en zoológicos. El grupo etarioinfluenció los niveles de eritrocitos, proteínas totales, bilirrubina total, colesterol yfosfatasa alcalina; asimismo, no hubo diferencias por efecto del sexo en la serie eritrocítica, conteo de plaquetas y bioquímica sérica, con excepción del número de monocitos.The objective of this study was to determine the haematological and serum biochemistry values in a population of woolly monkeys choros (Lagothrix lagotricha)reared in semi-captivity at the Centro de Rescate y Rehabilitación Ikamaperu in Lagunas, Loreto, Peru. Forty primates, 12 males and 28 females, which included juveniles, subadults and adults in apparent good health conditions were sampled. The haematological values were similar, triglyceride and AST values were elevated, and total protein and ALP values were low as compared to other studies in zoos. The age group influenced erythrocyte counts, total protein, total bilirubin, cholesterol and alkaline phosphatase. No sex effect was found on erythrocytes, leukocytes and platelet counts and in serum chemistry values, except for the number of monocytes

Nuclear 11.3μm PAH emission in local active galactic nuclei

A. Alonso-Herrero et al.We present Gran Telescopio CANARIAS CanariCam 8.7 μm imaging and 7.5-13 μm spectroscopy of six local systems known to host an active galactic nucleus (AGN) and have nuclear star formation. Our main goal is to investigate whether the molecules responsible for the 11.3 μm polycyclic aromatic hydrocarbon (PAH) feature are destroyed in the close vicinity of an AGN. We detect 11.3 μm PAH feature emission in the nuclear regions of the galaxies as well as extended PAH emission over a few hundred parsecs. The equivalent width (EW) of the feature shows a minimum at the nucleus but increases with increasing radial distances, reaching typical star-forming values a few hundred parsecs away from the nucleus. The reduced nuclear EWs are interpreted as due to increased dilution from the AGN continuum rather than destruction of the PAH molecules. We conclude that at least those molecules responsible for the 11.3 μm PAH feature survive in the nuclear environments as close as 10 pc from the AGN and for Seyfert-like AGN luminosities. We propose that material in the dusty tori, nuclear gas discs, and/or host galaxies of AGN is likely to provide the column densities necessary to protect the PAH molecules from the AGN radiation field. © 2014 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society.AA-H and AH-C are partly funded by the Universidad de Cantabria through the Augusto G. Linares programme. AA-H and AH-C acknowledge financial support from the Spanish Plan Nacional grant AYA2012-31447, AA-H and PE from grant AYA2009-05705-E, CRA from grant AYA2010-21887-C04.4 (Estallidos), PE from grant AYA2012-31277, and LC from grant AYA2012-32295. CRA acknowledges financial support from the Marie Curie Intra European Fellowship within the 7th European Community Framework Programme (PIEF-GA-2012-327934) and SFH from the Marie Curie International Incoming Fellowship within the 7th European Community Framework Programme (PIIFGA-2013-623804).Peer Reviewe

Factors related to the development of high antibody titres against SARS-CoV-2 in convalescent plasma donors from the ConPlas-19 trial

Background and objectives: The efficacy of COVID-19 convalescent plasma (CP) associates with high titres of antibodies. ConPlas-19 clinical trial showed that CP reduces the risk of progression to severe COVID-19 at 28 days. Here, we aim to study ConPlas-19 donors and characteristics that associate with high anti-SARS-CoV-2 antibody levels. Materials and methods: Four-hundred donors were enrolled in ConPlas-19. The presence and titres of anti-SARS-CoV-2 antibodies were evaluated by EUROIMMUN anti-SARS-CoV-2 S1 IgG ELISA. Results: A majority of 80.3% of ConPlas-19 donor candidates had positive EUROIMMUN test results (ratio ≥1.1), and of these, 51.4% had high antibody titres (ratio ≥3.5). Antibody levels decline over time, but nevertheless, out of 37 donors tested for an intended second CP donation, over 90% were still EUROIMMUN positive, and nearly 75% of those with high titres maintained high titres in the second sample. Donors with a greater probability of developing high titres of anti-SARS-CoV-2 antibodies include those older than 40 years of age (RR 2.06; 95% CI 1.24-3.42), with more than 7 days of COVID-19 symptoms (RR 1.89; 95% CI 1.05-3.43) and collected within 4 months from infection (RR 2.61; 95% CI 1.16-5.90). Male donors had a trend towards higher titres compared with women (RR 1.67; 95% CI 0.91-3.06). Conclusion: SARS-CoV-2 CP candidate donors' age, duration of COVID-19 symptoms and time from infection to donation associate with the collection of CP with high antibody levels. Beyond COVID-19, these data are relevant to inform decisions to optimize the CP donor selection process in potential future outbreaks.European Regional Development Fund (FEDER); Government of Spain, Ministry of Science and Innovation, Instituto de Salud Carlos III, Grant/Award Number: COV20/00072; SCReN (Spanish Clinical Research Network), Instituto de Salud Carlos III, Grant/Award Number: PT17/0017/0009S